NIK SMI1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NIK SMI1 是一种有效的选择性 NF-κB 诱导激酶 (NIK) 小分子抑制剂，Ki 为 230±170 pM。

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.

——

——

NIK SMI1 | NIKSMI1 | NIK-SMI1

Apoptosis

NF-κB

NF-κB

——

——

1660114-31-7

365.389

C20H19N3O4

>98% (HPLC)

DMSO : 100 mg/mL 273.69 mM

O=C(N)C1=NC(C2=CC=CC(C#C[C@@]3(O)C(N(C)CC3)=O)=C2)=CC(OC)=C1

(R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

(-20℃)

With Ice Pack

≥ 2 years